Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome
نویسندگان
چکیده
منابع مشابه
Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome.
Heart disease remains the leading cause of death and disability in the Western world. Current therapies aim at treating the symptoms rather than the subcellular mechanisms, underlying the etiology and pathological remodeling in heart failure. A universal characteristic, contributing to the decreased contractile performance in human and experimental failing hearts, is impaired calcium sequestrat...
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Modulation of cardiac contractility. A potential treatment of heart failure?
During the last 10 years, electrical treatment of heart failure (HF) has become more and more popular. Cardiac resynchronization therapy (CRT), alone or combined with defibrillation, has been confirmed to be effective in patients with moderate or severe HF and ventricular dyssynchrony, manifest as a QRS duration .120 ms, though its effectiveness has not been confirmed in patients presenting wit...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.111.259754